HEA567 Pharmacology For Health Professionals

Academic Anxiety?

Get an original paper within hours and nail the task

156 experts online

Free Samples

HEA567 Pharmacology For Health Professionals

.cms-body-content table{width:100%!important;} #subhidecontent{ position: relative;
overflow-x: auto;
width: 100%;}

HEA567 Pharmacology For Health Professionals

0 Download5 Pages / 1,230 Words

Course Code: HEA567
University: Charles Darwin University

MyAssignmentHelp.com is not sponsored or endorsed by this college or university

Country: Australia

Reflective Journal 1- Monoclonal Antibody Drugs
Reflect on your understanding with regard to Immunology and the current rapid development and introduction of monoclonal antibody drugs into clinical practice (they are mainly used as anti-inflammatory agents or cancer chemotherapeutic agents).  Use one example to elaborate your reflection and how this may lead to personalised medical treatment in future.

Reflective Journal One: Monoclonal Antibody Drugs
Monoclonal Antibody Drugs
Targeting of tumor- causing macrophages is becoming increasingly important in cancer treatment. Monoclonal antibodies (mAbs) have proved to be essential in cancer treatment due to their superior affinity for target antigens, specificity1 and blocking mechanism. Cancer patients of all kinds can benefit immensely from this tool. In this journal, we focus on how mAbs is used in the treatment of breast cancer with a touch of its possible utilization in personalized medical care in future.
Panowski et al. opine that targeted therapies work by means of a blocking mechanism that impedes the operations of essential biochemical pathways. In addition, they also block mutant proteins that are vital for tumor cell proliferation and survival2. In doing so, mAbs slow down tumor progression and stimulate considerable retrogressions in molecularly expressed subsets of cancer patients. BCR-ABL kinase inhibitor imatinib was the initial molecule known to have stimulated comprehensive cytogenetic responses in nearly 80% of chronic myelogenous leukemia patients3. The kinase inhibition capability has found use in treatment of many types of cancers. Future personalized medical care ought to take the abilities of mAbs with regards to BCR-ABL kinase imatinib inhibition into consideration in making giving the tool priority in patients whose metastatic cancer is at the initial stages.
Emerging Drug-resistant Variants
Further investigations into the genetic pathways driving tumor growth and nourishment have revealed additional oncoproteins that are essential for their sustenance. They include epidermal growth factor receptor (EGFR), BRAF, KIT, as well as anaplastic lymphoma kinase (ALK) 4. Imatinib has an analogous effect. Tiny molecule inhibitors of the kinases have been known to continuous notable tumor regressions in selected patients. Nevertheless, recessions are habitually trailed by a gradual development of the disease secondary to emerging drug-resistant variants5. Resistance has been associated with resultant mutations occurring in the affected protein as well as compensatory alterations occurring in the affected pathway consequently circumventing the drug-interceded inhibition6 &7. Consequently, targeted rehabilitation may prompt remarkable tumor regressions that are usually transient thereby constraining the general clinical advantage8. This is crucial information for clinicians to make determinations in using targeted therapies as a transitory cancer medication. By so doing, future cancer treatment would have personalized medical for each patient in a manner that meets the needs of the present with little compromise, if any.
Molecular procedures with capabilities to modify antibody pharmacokinetics, effector function, range, and immune-capabilities keep presenting themselves as crucial features in the development of innovative antibody-centered treatments. There exist substantiated claims based on clinical experiments of antibodies among cancer patients with regards to the significance of iterative tactics in the assortment of antigen marks and optimum antibodies. This constitutes the avidity and affinity (which are traits of antibodies). The selection of antibody structure and therapeutic tactic (inclusive of indication of retraction or immune effector function) as well as the prerequisite to thoroughly scrutinize the pharmacokinetic and pharmacodynamic characteristics of antibodies are important considerations in future clinical trials in their early stages.
Personalized medical treatment needs to take into account the nature of the target antigen in the computation of safety and efficacy of therapeutic mAbs. It is preferable that that copious amount of the antigen exists singularly on the exterior of cancer cells9. The release of antigen ought to be marginal considering their capability to bind the antibody circulating with a possible consequent effect of inhibiting ample antibody binding the tumour10. In case the preferred mechanism of action is either ADCC or CDC, then it is appropriate that the antigen–mAb composite is not promptly internalized in order to amplify the accessibility of the Fc locale of the immune effector cells in addition to complement proteins11. Contrastingly, suitable internalization is enviable in the events that antibodies or proteins used to delivering toxins into the cancer cell are available12. How does affect the personalization of medical? Well, different metastatic cancer cells react to mAbs treatment with dissimilar efficacies. As such, targeting will need to be done in clusters of patients with metastatic cancer cell whose mAbs treatment elicits the highest efficacy and safety alike.
Significant efforts have been put towards pinpointing new antigen targets appropriate for antibody-derived treatments in cancer. The fruitful development of suitable antibodies does entail an intricate procedure of scientific and preclinical observations, abreast by profound comprehension of cancer biology as well as the characteristics of antibodies13&14. All these are done at the backdrop of a keen interest in observing the efficacy and safety with regards to the stage of use15. This is made possible by the fact that mAbs have the capabilities to modify antibody pharmacokinetics, effector function, range and immune-capabilities keep presenting themselves as crucial features in the development of innovative antibody-centered treatments. 
Reference List
Panowski S, Bhakta S, Raab H, Polakis P, Junutula JR. Site-specific antibody-drug conjugates for cancer therapy. mAbs 2014 Jan 1 (Vol. 6, No. 1, pp. 34-45). Taylor & Francis.
Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nature reviews cancer. 2012 Apr;12(4):237.
Hughes TP, Hochhaus A, Branford S, Müller MC, Kaeda JS, Foroni L, Druker BJ, Guilhot F, Larson RA, O’Brien SG, Rudoltz MS. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the international randomized study of interferon versus STI571 (IRIS). Blood. 2010 Jan 1:blood-2010.
Haber DA, Gray NS, Baselga J. The evolving war on cancer.Cell.2011;145:19–24.
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baselga J. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. New England Journal of Medicine. 2001 Mar 15;344(11):783-92.
Adams GP, Weiner LM. Monoclonal antibody therapy of cancer. Nature biotechnology. 2005 Sep;23(9):1147.
Scott AM, Wolchok JD, Old LJ. Antibody therapy of cancer. Nature Reviews Cancer. 2012 Apr;12(4):278.
Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Advanced drug delivery reviews. 2012 Dec 1;64:206-12.
Weiner LM, Surana R, Wang S. Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nature Reviews Immunology. 2010 May;10(5):317.
Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012 Jun;486(7404):532.
Guo Y, Xu F, Lu T, Duan Z, Zhang Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer treatment reviews. 2012 Nov 1;38(7):904-10.
Rowland A, Dias MM, Wiese MD, Kichenadasse G, McKinnon RA, Karapetis CS, Sorich MJ. Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer. British journal of cancer. 2015 Jun;112(12):1888.
Burris III HA, Rugo HS, Vukelja SJ, Vogel CL, Borson RA, Limentani S, Tan-Chiu E, Krop IE, Michaelson RA, Girish S, Amler L. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)–positive breast cancer after prior HER2-directed therapy. Journal of Clinical Oncology. 2010 Dec 20;29(4):398-405.
Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey-Giraud F, Pradel LP, Feuerhake F, Klaman I, Jones T. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer cell. 2014 Jun 16;25(6):846-59.
Ecker DM, Jones SD, Levine HL. The therapeutic monoclonal antibody market. InMAbs 2015 Jan 2 (Vol. 7, No. 1, pp. 9-14). Taylor & Francis.

Free Membership to World’s Largest Sample Bank

To View this & another 50000+ free samples. Please put
your valid email id.


Yes, alert me for offers and important updates


Download Sample Now

Earn back the money you have spent on the downloaded sample by uploading a unique assignment/study material/research material you have. After we assess the authenticity of the uploaded content, you will get 100% money back in your wallet within 7 days.

UploadUnique Document

DocumentUnder Evaluation

Get Moneyinto Your Wallet

Total 5 pages


*The content must not be available online or in our existing Database to qualify as

Cite This Work
To export a reference to this article please select a referencing stye below:


My Assignment Help. (2021). Pharmacology For Health Professionals. Retrieved from https://myassignmenthelp.com/free-samples/hea567-pharmacology-for-health-professionals/monoclonal-antibody-drugs.html.

“Pharmacology For Health Professionals.” My Assignment Help, 2021, https://myassignmenthelp.com/free-samples/hea567-pharmacology-for-health-professionals/monoclonal-antibody-drugs.html.

My Assignment Help (2021) Pharmacology For Health Professionals [Online]. Available from: https://myassignmenthelp.com/free-samples/hea567-pharmacology-for-health-professionals/monoclonal-antibody-drugs.html[Accessed 18 December 2021].

My Assignment Help. ‘Pharmacology For Health Professionals’ (My Assignment Help, 2021) accessed 18 December 2021.

My Assignment Help. Pharmacology For Health Professionals [Internet]. My Assignment Help. 2021 [cited 18 December 2021]. Available from: https://myassignmenthelp.com/free-samples/hea567-pharmacology-for-health-professionals/monoclonal-antibody-drugs.html.

.close{position: absolute;right: 5px;z-index: 999;opacity: 1;color: #ff8b00;}


Thank you for your interest
The respective sample has been mail to your register email id


$20 Credited
successfully in your wallet.
* $5 to be used on order value more than $50. Valid for
only 1

Account created successfully!
We have sent login details on your registered email.



MyAssignmenthelp.com has become one of the leading assignment help provider in New York City and Boston. We provide top class auditing assignment help. Not only auditing, but we also cover more than 100 subjects and our writers deal with all types of assignments with utmost expertise. To make writing process faster and accurate, we have segmented our assignment experts’ teams as per their expertise on writing different types of assignments. We guaranteed that students who buy our assignment online get solutions worth their investment.

Latest Healthcare Samples

div#loaddata .card img {max-width: 100%;

5N1794 Safety And Health At Work
Download :
0 | Pages :

Course Code: 5N1794
University: University College Cork

MyAssignmentHelp.com is not sponsored or endorsed by this college or university

Country: Ireland

Assignment 1
Answer to question 1
I have conducted a survey at my workplace maned Lady’s Hospice and Care Services to observe the working environment. The aim of the survey is to find if it is a safe, healthy, secured and fulfilling place to work. A visual survey was conducted to locate and record the safety signs in the workplace. The objective of the survey is to observe and list different types of signs, location, their prom…
Australia Maple Ridge Management Introduction to film studies University of New South Wales Masters in Business Administration 

400837 Health And Socio Political Issues In Aged Care
Download :
0 | Pages :

Course Code: 400837
University: Western Sydney University

MyAssignmentHelp.com is not sponsored or endorsed by this college or university

Country: Australia

Palliative care services are designed to improve the life of patient with progressive disease. People receiving palliative care have illness that has no prospect of cure.  As per the World Health Organisation, palliative care is a care given to patient suffering from life threatening illness to improve their quality of life by preventing and providing relief from sufferings by early recognition , assessment and trea…
Australia Minchinbury Management University of New South Wales 

PUBH6304 Global Health
Download :
0 | Pages :

Course Code: PUBH6304
University: The University Of Newcastle

MyAssignmentHelp.com is not sponsored or endorsed by this college or university

Country: Australia

Human Immunodeficiency Virus Infection and Acquired Immune Deficiency Syndrome (HIV/AIDS) is the spectrum of medical conditions caused due to human immunodeficiency virus (HIV) following which the patient suffers from a series medical complications due to suppression of the immune system of the body. With the progression of the disease, the patient is likely to suffer from a wide range of infections like tuberculosis and other opportu…
United States Newark Management University of New York Masters in Business Administration 

CON 321 Health Related Research
Download :
0 | Pages :

Course Code: CON321
University: University Of Southern Maine

MyAssignmentHelp.com is not sponsored or endorsed by this college or university

Country: United States

Leadership in the hospital is the ability to influence the staff toward providing quality health care. Leadership involves influencing human behavior to create a positive working environment (Langlois, 2012). Good leadership enables healthy relationships among staffs in the hospital enhancing quality delivery of health care services. Leadership is responsible to building teams that have trust, respect, support and effecti…

BL9412 Public Health
Download :
0 | Pages :

Course Code: BL9412
University: University Of The West Of England

MyAssignmentHelp.com is not sponsored or endorsed by this college or university

Country: United Kingdom

According to the researchers, it can be said that the management of the health care organizations has become a difficult task nowadays and the reason behind this is the occurrence of various issues in this sector (Hall et al., 2014). Therefore, the administrative employees of the organization should incorporate various revolutionized strategies for enriching the worth of care provided by the hospital to its clients and re…
Australia Ryde Management Information system strategy University of New South Wales (UNSW) Masters in Business Administration 


Need an essay written specifically to meet your requirements?

Choose skilled experts on your subject and get an original paper within your deadline

156 experts online

Your time is important. Let us write you an essay from scratch

Tips and Tricks from our Blog